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Structural characterization of the HCoV-229E fusion core

HCoV-229E spike (S) protein mediates virion attachment to cells and subsequent fusion of the viral and cellular membranes. This protein is composed of an N-terminal receptor-binding domain (S1) and a C-terminal trans-membrane fusion domain (S2). S2 contains a highly conserved heptad repeat 1 and 2 (...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Zheng, Qianqian, Yan, Mengrong, Chen, Xiaobo, Yang, Haitao, Zhou, Weihong, Rao, Zihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092869/
https://www.ncbi.nlm.nih.gov/pubmed/29458023
http://dx.doi.org/10.1016/j.bbrc.2018.02.136