The SARS-CoV heptad repeat 2 exhibits pH-induced helix formation

The heptad repeats 1 and 2 of SARS-CoV spike, termed HR1 and HR2, play critical roles in viral entry. Moreover, HR1 and HR2 derived free peptides are inhibitors of SARS-CoV entry. In this work we used circular dichroism to show that HR2 helix formation is induced at pH 5, the pH of the endosome. In...

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Detalles Bibliográficos
Autores principales: Celigoy, Jessica, McReynolds, Susanna, Caffrey, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092892/
https://www.ncbi.nlm.nih.gov/pubmed/21835164
http://dx.doi.org/10.1016/j.bbrc.2011.07.126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092892/
https://www.ncbi.nlm.nih.gov/pubmed/21835164
http://dx.doi.org/10.1016/j.bbrc.2011.07.126

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