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The SARS-CoV heptad repeat 2 exhibits pH-induced helix formation

The heptad repeats 1 and 2 of SARS-CoV spike, termed HR1 and HR2, play critical roles in viral entry. Moreover, HR1 and HR2 derived free peptides are inhibitors of SARS-CoV entry. In this work we used circular dichroism to show that HR2 helix formation is induced at pH 5, the pH of the endosome. In...

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Detalles Bibliográficos
Autores principales:	Celigoy, Jessica, McReynolds, Susanna, Caffrey, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092892/ https://www.ncbi.nlm.nih.gov/pubmed/21835164 http://dx.doi.org/10.1016/j.bbrc.2011.07.126

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