ARV-825-induced BRD4 protein degradation as a therapy for thyroid carcinoma

Bromodomain-containing protein 4 (BRD4) is overexpressed in thyroid carcinoma, represents as an important therapeutic target. ARV-825 is a novel cereblon-based PROTAC (Proteolysis Targeting Chsimera) compound. It can induce fast and sustained BRD4 protein degradation. Its potential effect in human t...

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Detalles Bibliográficos
Autores principales: He, Ling, Chen, Chen, Gao, Guoyu, Xu, Kun, Ma, Zhaoqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093165/
https://www.ncbi.nlm.nih.gov/pubmed/32163373
http://dx.doi.org/10.18632/aging.102910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093165/
https://www.ncbi.nlm.nih.gov/pubmed/32163373
http://dx.doi.org/10.18632/aging.102910

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