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ARV-825-induced BRD4 protein degradation as a therapy for thyroid carcinoma

Bromodomain-containing protein 4 (BRD4) is overexpressed in thyroid carcinoma, represents as an important therapeutic target. ARV-825 is a novel cereblon-based PROTAC (Proteolysis Targeting Chsimera) compound. It can induce fast and sustained BRD4 protein degradation. Its potential effect in human t...

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Detalles Bibliográficos
Autores principales:	He, Ling, Chen, Chen, Gao, Guoyu, Xu, Kun, Ma, Zhaoqun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093165/ https://www.ncbi.nlm.nih.gov/pubmed/32163373 http://dx.doi.org/10.18632/aging.102910

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