SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt–STAT5–Trib1 Circuit in Pseudomonas aeruginosa Infection

SHIP-1 is an inositol phosphatase that hydrolyzes phosphatidylinositol 3-kinase (PI3K) products and negatively regulates protein kinase B (Akt) activity, thereby modulating a variety of cellular processes in mammals. However, the role of SHIP-1 in bacterial-induced sepsis is largely unknown. Here, w...

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Detalles Bibliográficos
Autores principales: Qin, Shugang, Li, Jiaxin, Zhou, Chuanmin, Privratsky, Breanna, Schettler, Jacob, Deng, Xin, Xia, Zhenwei, Zeng, Yong, Wu, Hong, Wu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093384/
https://www.ncbi.nlm.nih.gov/pubmed/32256487
http://dx.doi.org/10.3389/fimmu.2020.00307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093384/
https://www.ncbi.nlm.nih.gov/pubmed/32256487
http://dx.doi.org/10.3389/fimmu.2020.00307

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