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Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
Aging is characterized by a gradual loss of function occurring at the molecular, cellular, tissue and organismal levels. At the chromatin level, aging associates with progressive accumulation of epigenetic errors that eventually lead to aberrant gene regulation, stem cell exhaustion, senescence, and...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093390/ https://www.ncbi.nlm.nih.gov/pubmed/32210226 http://dx.doi.org/10.1038/s41467-020-15174-3 |