CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models

The major barrier to a HIV-1 cure is the persistence of latent genomes despite treatment with antiretrovirals. To investigate host factors which promote HIV-1 latency, we conducted a genome-wide functional knockout screen using CRISPR-Cas9 in a HIV-1 latency cell line model. This screen identified I...

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Detalles Bibliográficos
Autores principales: Rathore, Anurag, Iketani, Sho, Wang, Pengfei, Jia, Manxue, Sahi, Vincent, Ho, David D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093534/
https://www.ncbi.nlm.nih.gov/pubmed/32210344
http://dx.doi.org/10.1038/s41598-020-62375-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093534/
https://www.ncbi.nlm.nih.gov/pubmed/32210344
http://dx.doi.org/10.1038/s41598-020-62375-3

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