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CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models

The major barrier to a HIV-1 cure is the persistence of latent genomes despite treatment with antiretrovirals. To investigate host factors which promote HIV-1 latency, we conducted a genome-wide functional knockout screen using CRISPR-Cas9 in a HIV-1 latency cell line model. This screen identified I...

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Detalles Bibliográficos
Autores principales:	Rathore, Anurag, Iketani, Sho, Wang, Pengfei, Jia, Manxue, Sahi, Vincent, Ho, David D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093534/ https://www.ncbi.nlm.nih.gov/pubmed/32210344 http://dx.doi.org/10.1038/s41598-020-62375-3

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