Klf6 protects β-cells against insulin resistance-induced dedifferentiation

OBJECTIVES: In the pathogenesis of type 2 diabetes, development of insulin resistance triggers an increase in pancreatic β-cell insulin secretion capacity and β-cell number. Failure of this compensatory mechanism is caused by a dedifferentiation of β-cells, which leads to insufficient insulin secret...

Descripción completa

Detalles Bibliográficos
Autores principales: Dumayne, Christopher, Tarussio, David, Sanchez-Archidona, Ana Rodriguez, Picard, Alexandre, Basco, Davide, Berney, Xavier Pascal, Ibberson, Mark, Thorens, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093812/
https://www.ncbi.nlm.nih.gov/pubmed/32244185
http://dx.doi.org/10.1016/j.molmet.2020.02.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093812/
https://www.ncbi.nlm.nih.gov/pubmed/32244185
http://dx.doi.org/10.1016/j.molmet.2020.02.001

Ejemplares similares