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Klf6 protects β-cells against insulin resistance-induced dedifferentiation

OBJECTIVES: In the pathogenesis of type 2 diabetes, development of insulin resistance triggers an increase in pancreatic β-cell insulin secretion capacity and β-cell number. Failure of this compensatory mechanism is caused by a dedifferentiation of β-cells, which leads to insufficient insulin secret...

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Detalles Bibliográficos
Autores principales:	Dumayne, Christopher, Tarussio, David, Sanchez-Archidona, Ana Rodriguez, Picard, Alexandre, Basco, Davide, Berney, Xavier Pascal, Ibberson, Mark, Thorens, Bernard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093812/ https://www.ncbi.nlm.nih.gov/pubmed/32244185 http://dx.doi.org/10.1016/j.molmet.2020.02.001

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