Mutational Analysis of the SARS Virus Nsp15 Endoribonuclease: Identification of Residues Affecting Hexamer Formation

The severe acute respiratory syndrome (SARS) coronavirus virus non-structural protein 15 is a Mn(2+)-dependent endoribonuclease with specificity for cleavage at uridylate residues. To better understand structural and functional characteristics of Nsp15, 22 mutant versions of Nsp15 were produced in E...

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Detalles Bibliográficos
Autores principales: Guarino, Linda A., Bhardwaj, Kanchan, Dong, Wen, Sun, Jingchuan, Holzenburg, Andreas, Kao, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094243/
https://www.ncbi.nlm.nih.gov/pubmed/16216269
http://dx.doi.org/10.1016/j.jmb.2005.09.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094243/
https://www.ncbi.nlm.nih.gov/pubmed/16216269
http://dx.doi.org/10.1016/j.jmb.2005.09.007

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