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Mutational Analysis of the SARS Virus Nsp15 Endoribonuclease: Identification of Residues Affecting Hexamer Formation

The severe acute respiratory syndrome (SARS) coronavirus virus non-structural protein 15 is a Mn(2+)-dependent endoribonuclease with specificity for cleavage at uridylate residues. To better understand structural and functional characteristics of Nsp15, 22 mutant versions of Nsp15 were produced in E...

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Detalles Bibliográficos
Autores principales:	Guarino, Linda A., Bhardwaj, Kanchan, Dong, Wen, Sun, Jingchuan, Holzenburg, Andreas, Kao, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094243/ https://www.ncbi.nlm.nih.gov/pubmed/16216269 http://dx.doi.org/10.1016/j.jmb.2005.09.007

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