Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

CD40-stimulating immunotherapy can elicit potent anti-tumor responses by activating dendritic cells and enhancing T-cell priming. Tumor vessels orchestrate T-cell recruitment during immune response, but the effect of CD40-stimulating immunotherapy on tumor endothelial cells has not been evaluated. H...

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Detalles Bibliográficos
Autores principales: Georganaki, Maria, Ramachandran, Mohanraj, Tuit, Sander, Núñez, Nicolás Gonzalo, Karampatzakis, Alexandros, Fotaki, Grammatiki, van Hooren, Luuk, Huang, Hua, Lugano, Roberta, Ulas, Thomas, Kaunisto, Aura, Holland, Eric C, Ellmark, Peter, Mangsbo, Sara M, Schultze, Joachim, Essand, Magnus, Tugues, Sonia, Dimberg, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094447/
https://www.ncbi.nlm.nih.gov/pubmed/32231867
http://dx.doi.org/10.1080/2162402X.2020.1730538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094447/
https://www.ncbi.nlm.nih.gov/pubmed/32231867
http://dx.doi.org/10.1080/2162402X.2020.1730538

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