The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners

NADPH cytochrome P450 oxidoreductase (CPR) is the obligatory electron supplier that sustains the activity of microsomal cytochrome P450 (CYP) enzymes. The variant nature of the isoform-specific proximal interface of microsomal CYPs indicates that CPR is capable of multiple degenerated interactions w...

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Detalles Bibliográficos
Autores principales: Esteves, Francisco, Campelo, Diana, Gomes, Bruno Costa, Urban, Philippe, Bozonnet, Sophie, Lautier, Thomas, Rueff, José, Truan, Gilles, Kranendonk, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094780/
https://www.ncbi.nlm.nih.gov/pubmed/32256365
http://dx.doi.org/10.3389/fphar.2020.00299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094780/
https://www.ncbi.nlm.nih.gov/pubmed/32256365
http://dx.doi.org/10.3389/fphar.2020.00299

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