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An in-silico human cell model reveals the influence of spatial organization on RNA splicing

Spatial organization is a characteristic of all cells, achieved in eukaryotic cells by utilizing both membrane-bound and membrane-less organelles. One of the key processes in eukaryotes is RNA splicing, which readies mRNA for translation. This complex and highly dynamical chemical process involves a...

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Detalles Bibliográficos
Autores principales: Ghaemi, Zhaleh, Peterson, Joseph R., Gruebele, Martin, Luthey-Schulten, Zaida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094823/
https://www.ncbi.nlm.nih.gov/pubmed/32210422
http://dx.doi.org/10.1371/journal.pcbi.1007717