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Identification of clinically approved small molecules that inhibit growth and affect transcript levels of developmentally regulated genes in the African trypanosome

Trypanosoma brucei are unicellular parasites endemic to Sub-Saharan Africa that cause fatal disease in humans and animals. Infection with these parasites is caused by the bite of the tsetse fly vector, and parasites living extracellularly in the blood of infected animals evade the host immune system...

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Detalles Bibliográficos
Autores principales: Walsh, Madison Elle, Naudzius, Eleanor Mary, Diaz, Savanah Jessica, Wismar, Theodore William, Martchenko Shilman, Mikhail, Schulz, Danae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094864/
https://www.ncbi.nlm.nih.gov/pubmed/32168320
http://dx.doi.org/10.1371/journal.pntd.0007790