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A kinesin Klp10A mediates cell cycle-dependent shuttling of Piwi between nucleus and nuage

The piRNA pathway protects germline genomes from selfish genetic elements (e.g. transposons) through their transcript cleavage in the cytoplasm and/or their transcriptional silencing in the nucleus. Here, we describe a mechanism by which the nuclear and cytoplasmic arms of the piRNA pathway are link...

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Detalles Bibliográficos
Autores principales: Venkei, Zsolt G., Choi, Charlotte P., Feng, Suhua, Chen, Cuie, Jacobsen, Steven E., Kim, John K., Yamashita, Yukiko M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094869/
https://www.ncbi.nlm.nih.gov/pubmed/32168327
http://dx.doi.org/10.1371/journal.pgen.1008648