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Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase

Leukotoxin is a linoleic acic oxide produced by leukocytes and has been associated with the multiple organ failure and adult respiratory distress syndrome seen in some severe burn patients. Leukotoxin has been reported to be toxic when injected into animals intravenously. Herein, we report that this...

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Detalles Bibliográficos
Autores principales: Moghaddam, Mehran F., Grant, David F., Cheek, Jeffrey M., Greene, Jessica F., Williamson, Kristin C., Hammock, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 1997
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095900/
https://www.ncbi.nlm.nih.gov/pubmed/9142128
http://dx.doi.org/10.1038/nm0597-562