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gp41: HIV's shy protein
The first X-ray crystal structures of gp41, the protein that mediates fusion of HIV-1 to target cells, were solved in the mid-1990s. The structures provide a foundation for understanding viral entry and the mechanism of action of compounds that block fusion. The first fusion inhibitor has recently e...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group US
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095992/ https://www.ncbi.nlm.nih.gov/pubmed/14760422 http://dx.doi.org/10.1038/nm0204-133 |
| Sumario: | The first X-ray crystal structures of gp41, the protein that mediates fusion of HIV-1 to target cells, were solved in the mid-1990s. The structures provide a foundation for understanding viral entry and the mechanism of action of compounds that block fusion. The first fusion inhibitor has recently entered the clinic, and the hope is that more potent and broadly active compounds, based on molecular design, will follow. |
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