gp41: HIV's shy protein

The first X-ray crystal structures of gp41, the protein that mediates fusion of HIV-1 to target cells, were solved in the mid-1990s. The structures provide a foundation for understanding viral entry and the mechanism of action of compounds that block fusion. The first fusion inhibitor has recently e...

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Detalles Bibliográficos
Autores principales: Zwick, Michael B, Saphire, Erica O, Burton, Dennis R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095992/
https://www.ncbi.nlm.nih.gov/pubmed/14760422
http://dx.doi.org/10.1038/nm0204-133
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author Zwick, Michael B
Saphire, Erica O
Burton, Dennis R
author_facet Zwick, Michael B
Saphire, Erica O
Burton, Dennis R
author_sort Zwick, Michael B
collection PubMed
description The first X-ray crystal structures of gp41, the protein that mediates fusion of HIV-1 to target cells, were solved in the mid-1990s. The structures provide a foundation for understanding viral entry and the mechanism of action of compounds that block fusion. The first fusion inhibitor has recently entered the clinic, and the hope is that more potent and broadly active compounds, based on molecular design, will follow.
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spelling pubmed-70959922020-03-26 gp41: HIV's shy protein Zwick, Michael B Saphire, Erica O Burton, Dennis R Nat Med Article The first X-ray crystal structures of gp41, the protein that mediates fusion of HIV-1 to target cells, were solved in the mid-1990s. The structures provide a foundation for understanding viral entry and the mechanism of action of compounds that block fusion. The first fusion inhibitor has recently entered the clinic, and the hope is that more potent and broadly active compounds, based on molecular design, will follow. Nature Publishing Group US 2004 /pmc/articles/PMC7095992/ /pubmed/14760422 http://dx.doi.org/10.1038/nm0204-133 Text en © Nature Publishing Group 2004 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Zwick, Michael B
Saphire, Erica O
Burton, Dennis R
gp41: HIV's shy protein
title gp41: HIV's shy protein
title_full gp41: HIV's shy protein
title_fullStr gp41: HIV's shy protein
title_full_unstemmed gp41: HIV's shy protein
title_short gp41: HIV's shy protein
title_sort gp41: hiv's shy protein
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095992/
https://www.ncbi.nlm.nih.gov/pubmed/14760422
http://dx.doi.org/10.1038/nm0204-133
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AT saphireericao gp41hivsshyprotein
AT burtondennisr gp41hivsshyprotein

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