Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice

Pathological aggregates of tau proteins accumulate in the brains of neurodegenerative tauopathies including Alzheimer’s disease and frontotemporal lobar degeneration (FTLD-tau). Although immunotherapies of these disorders against tau are emerging, it is unknown whether nasal delivery, which offers m...

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Detalles Bibliográficos
Autores principales: Takeuchi, Hiroki, Imamura, Keiko, Ji, Bin, Tsukita, Kayoko, Enami, Takako, Takao, Keizo, Miyakawa, Tsuyoshi, Hasegawa, Masato, Sahara, Naruhiko, Iwata, Nobuhisa, Inoue, Makoto, Hara, Hideo, Tabira, Takeshi, Ono, Maiko, Trojanowski, John Q., Lee, Virginia M.-Y., Takahashi, Ryosuke, Suhara, Tetsuya, Higuchi, Makoto, Inoue, Haruhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096417/
https://www.ncbi.nlm.nih.gov/pubmed/32219000
http://dx.doi.org/10.1038/s41541-020-0172-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096417/
https://www.ncbi.nlm.nih.gov/pubmed/32219000
http://dx.doi.org/10.1038/s41541-020-0172-y

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