Development of a Genetically–Engineered, Candidate Polio Vaccine Employing the Self–Assembling Properties of the Tobacco Mosaic Virus Coat Protein

A synthetic gene coding for the coat protein of tobacco mosaic virus (TMVCP) was expressed in E. coli under the direction of the lacUV5 promoter. Modification of the 3′ end of the TMVCP gene by insertion of a region coding for an antigenic epitope from poliovirus type 3 resulted in the production of...

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Detalles Bibliográficos
Autores principales: Haynes, Joel R., Cunningham, Janet, von Seefried, Adolph, Lennick, Michael, Garvin, Robert T., Shen, Shi-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 1986
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097054/
https://www.ncbi.nlm.nih.gov/pubmed/32226216
http://dx.doi.org/10.1038/nbt0786-637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097054/
https://www.ncbi.nlm.nih.gov/pubmed/32226216
http://dx.doi.org/10.1038/nbt0786-637

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