Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytes

Gonococci that bind the coinhibitory receptor CEACAM1 appear to down-regulate the activation and proliferation of CD4(+) T cells. Such infection-induced immunosuppression helps explain why there is little specific immune response associated with gonococcal disease.

Detalles Bibliográficos
Autores principales: Normark, Staffan, Albiger, Barbara, Jonsson, Ann-Beth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097558/
https://www.ncbi.nlm.nih.gov/pubmed/11875456
http://dx.doi.org/10.1038/ni0302-210
Descripción
Sumario:Gonococci that bind the coinhibitory receptor CEACAM1 appear to down-regulate the activation and proliferation of CD4(+) T cells. Such infection-induced immunosuppression helps explain why there is little specific immune response associated with gonococcal disease.

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