Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytes

Gonococci that bind the coinhibitory receptor CEACAM1 appear to down-regulate the activation and proliferation of CD4(+) T cells. Such infection-induced immunosuppression helps explain why there is little specific immune response associated with gonococcal disease.

Detalles Bibliográficos
Autores principales: Normark, Staffan, Albiger, Barbara, Jonsson, Ann-Beth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097558/
https://www.ncbi.nlm.nih.gov/pubmed/11875456
http://dx.doi.org/10.1038/ni0302-210
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author Normark, Staffan
Albiger, Barbara
Jonsson, Ann-Beth
author_facet Normark, Staffan
Albiger, Barbara
Jonsson, Ann-Beth
author_sort Normark, Staffan
collection PubMed
description Gonococci that bind the coinhibitory receptor CEACAM1 appear to down-regulate the activation and proliferation of CD4(+) T cells. Such infection-induced immunosuppression helps explain why there is little specific immune response associated with gonococcal disease.
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spelling pubmed-70975582020-03-26 Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytes Normark, Staffan Albiger, Barbara Jonsson, Ann-Beth Nat Immunol Article Gonococci that bind the coinhibitory receptor CEACAM1 appear to down-regulate the activation and proliferation of CD4(+) T cells. Such infection-induced immunosuppression helps explain why there is little specific immune response associated with gonococcal disease. Nature Publishing Group US 2002 /pmc/articles/PMC7097558/ /pubmed/11875456 http://dx.doi.org/10.1038/ni0302-210 Text en © Nature Publishing Group 2002 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Normark, Staffan
Albiger, Barbara
Jonsson, Ann-Beth
Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytes
title Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytes
title_full Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytes
title_fullStr Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytes
title_full_unstemmed Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytes
title_short Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytes
title_sort gonococci cause immunosuppression by engaging a coinhibitory receptor on t lymphocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097558/
https://www.ncbi.nlm.nih.gov/pubmed/11875456
http://dx.doi.org/10.1038/ni0302-210
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AT albigerbarbara gonococcicauseimmunosuppressionbyengagingacoinhibitoryreceptorontlymphocytes
AT jonssonannbeth gonococcicauseimmunosuppressionbyengagingacoinhibitoryreceptorontlymphocytes

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