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OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

Recent discoveries in the field of innate immunity have highlighted the existence of a family of nucleic acid-sensing proteins that have similar structural and functional properties. These include the well-known oligoadenylate synthase (OAS) family proteins and the recently identified OAS homologue...

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Detalles Bibliográficos
Autores principales: Hornung, Veit, Hartmann, Rune, Ablasser, Andrea, Hopfner, Karl-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097587/
https://www.ncbi.nlm.nih.gov/pubmed/25033909
http://dx.doi.org/10.1038/nri3719