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Deubiquitylating enzymes and drug discovery: emerging opportunities

More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors, first-generation deubiquitylating enzyme (DUB) inhibitors are now approaching clinical trials. However, although our knowled...

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Detalles Bibliográficos
Autores principales: Harrigan, Jeanine A., Jacq, Xavier, Martin, Niall M., Jackson, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097658/
https://www.ncbi.nlm.nih.gov/pubmed/28959952
http://dx.doi.org/10.1038/nrd.2017.152