Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond

In less than 20 years, the first selective type 5 phosphodiesterase inhibitor, sildenafil, has evolved from a potential anti-angina drug to an on-demand oral treatment for erectile dysfunction (Viagra), and more recently to a new orally active treatment for pulmonary hypertension (Revatio). Here we...

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Detalles Bibliográficos
Autores principales: Ghofrani, Hossein A., Osterloh, Ian H., Grimminger, Friedrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097805/
https://www.ncbi.nlm.nih.gov/pubmed/16883306
http://dx.doi.org/10.1038/nrd2030
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author Ghofrani, Hossein A.
Osterloh, Ian H.
Grimminger, Friedrich
author_facet Ghofrani, Hossein A.
Osterloh, Ian H.
Grimminger, Friedrich
author_sort Ghofrani, Hossein A.
collection PubMed
description In less than 20 years, the first selective type 5 phosphodiesterase inhibitor, sildenafil, has evolved from a potential anti-angina drug to an on-demand oral treatment for erectile dysfunction (Viagra), and more recently to a new orally active treatment for pulmonary hypertension (Revatio). Here we describe the key milestones in the development of sildenafil for these diverse medical conditions, discuss the advances in science and clinical medicine that have accompanied this journey and consider possible future indications for this versatile drug.
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spelling pubmed-70978052020-03-26 Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond Ghofrani, Hossein A. Osterloh, Ian H. Grimminger, Friedrich Nat Rev Drug Discov Article In less than 20 years, the first selective type 5 phosphodiesterase inhibitor, sildenafil, has evolved from a potential anti-angina drug to an on-demand oral treatment for erectile dysfunction (Viagra), and more recently to a new orally active treatment for pulmonary hypertension (Revatio). Here we describe the key milestones in the development of sildenafil for these diverse medical conditions, discuss the advances in science and clinical medicine that have accompanied this journey and consider possible future indications for this versatile drug. Nature Publishing Group UK 2006 /pmc/articles/PMC7097805/ /pubmed/16883306 http://dx.doi.org/10.1038/nrd2030 Text en © Nature Publishing Group 2006 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Ghofrani, Hossein A.
Osterloh, Ian H.
Grimminger, Friedrich
Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
title Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
title_full Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
title_fullStr Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
title_full_unstemmed Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
title_short Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
title_sort sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097805/
https://www.ncbi.nlm.nih.gov/pubmed/16883306
http://dx.doi.org/10.1038/nrd2030
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AT grimmingerfriedrich sildenafilfromanginatoerectiledysfunctiontopulmonaryhypertensionandbeyond

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