The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells

Neuroblastoma (NB) is the most common extra-cranial solid tumor in childhood with the overall 5 years' survival less than 40%. Polo-like kinase 1 (PLK1) is a serine/threonine-protein kinase expressed during mitosis and over expressed in multiple cancers, including neuroblastoma. We found that h...

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Detalles Bibliográficos
Autores principales: Li, Zhiheng, Yang, Chun, Li, Xiaolu, Du, Xiaojuan, Tao, Yanfang, Ren, Junli, Fang, Fang, Xie, Yi, Li, Mei, Qian, Guanghui, Xu, Lixiao, Cao, Xu, Wu, Yi, Lv, Haitao, Hu, Shaoyan, Lu, Jun, Pan, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097946/
https://www.ncbi.nlm.nih.gov/pubmed/32231733
http://dx.doi.org/10.7150/jca.33110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097946/
https://www.ncbi.nlm.nih.gov/pubmed/32231733
http://dx.doi.org/10.7150/jca.33110

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