Down-regulation of protease-activated receptor 2 ameliorated osteoarthritis in rats through regulation of MAPK/NF-κB signaling pathway in vivo and in vitro

Recently, protease-activated receptor 2 (PAR2) has been proved to be involved in the inflammatory response including osteoarthritis (OA). In the present study, we found that PAR2 antagonist could remarkably improve the pathological condition of OA rats in vivo. In addition, we also found that PAR2 a...

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Detalles Bibliográficos
Autores principales: Yan, Shichang, Ding, Huimin, Peng, Junyang, Wang, Xinqiang, Pang, Chenglong, Wei, Juncheng, Wei, Jianjun, Chen, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098131/
https://www.ncbi.nlm.nih.gov/pubmed/32134473
http://dx.doi.org/10.1042/BSR20192620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098131/
https://www.ncbi.nlm.nih.gov/pubmed/32134473
http://dx.doi.org/10.1042/BSR20192620

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