Applying univariate vs. multivariate statistics to investigate therapeutic efficacy in (pre)clinical trials: A Monte Carlo simulation study on the example of a controlled preclinical neurotrauma trial

BACKGROUND: Small sample sizes combined with multiple correlated endpoints pose a major challenge in the statistical analysis of preclinical neurotrauma studies. The standard approach of applying univariate tests on individual response variables has the advantage of simplicity of interpretation, but...

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Detalles Bibliográficos
Autores principales: Todorov, Hristo, Searle-White, Emily, Gerber, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098614/
https://www.ncbi.nlm.nih.gov/pubmed/32214370
http://dx.doi.org/10.1371/journal.pone.0230798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098614/
https://www.ncbi.nlm.nih.gov/pubmed/32214370
http://dx.doi.org/10.1371/journal.pone.0230798

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