Nucleolar protein NOP2/NSUN1 suppresses HIV-1 transcription and promotes viral latency by competing with Tat for TAR binding and methylation

Recent efforts have been paid to identify previously unrecognized HIV-1 latency-promoting genes (LPGs) that can potentially be targeted for eradication of HIV-1 latent reservoirs. From our earlier orthologous RNAi screens of host factors regulating HIV-1 replication, we identified that the nucleolar...

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Detalles Bibliográficos
Autores principales: Kong, Weili, Biswas, Ayan, Zhou, Dawei, Fiches, Guillaume, Fujinaga, Koh, Santoso, Netty, Zhu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098636/
https://www.ncbi.nlm.nih.gov/pubmed/32176734
http://dx.doi.org/10.1371/journal.ppat.1008430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098636/
https://www.ncbi.nlm.nih.gov/pubmed/32176734
http://dx.doi.org/10.1371/journal.ppat.1008430

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