Evaluation of the effect of P‐glycoprotein inhibition and induction on talazoparib disposition in patients with advanced solid tumours

AIMS: In vitro data show that talazoparib is a substrate for P‐glycoprotein (P‐gp) and breast cancer resistance protein transporters. This open‐label, 2‐arm, drug–drug interaction Phase 1 study in patients with advanced solid tumours assessed the effect of a P‐gp inhibitor (itraconazole) and a P‐gp...

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Detalles Bibliográficos
Autores principales: Elmeliegy, Mohamed, Láng, István, Smolyarchuk, Elena A., Chung, Chin‐Hee, Plotka, Anna, Shi, Haihong, Wang, Diane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098856/
https://www.ncbi.nlm.nih.gov/pubmed/31770456
http://dx.doi.org/10.1111/bcp.14178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098856/
https://www.ncbi.nlm.nih.gov/pubmed/31770456
http://dx.doi.org/10.1111/bcp.14178

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