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Antibody humanization—the Influence of the antibody framework on the CDR-H3 loop ensemble in solution
Antibody engineering of non-human antibodies has focused on reducing immunogenicity by humanization, being a major limitation in developing monoclonal antibodies. We analyzed four series of antibody binding fragments (Fabs) and a variable fragment (Fv) with structural information in different stages...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098879/ https://www.ncbi.nlm.nih.gov/pubmed/32129452 http://dx.doi.org/10.1093/protein/gzaa004 |