Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia

A small proportion of patients with acute lymphoblastic leukemia (ALL) may experience severe leukopenia after treating with 6-mercaptopurine (6MP), which can be largely explained by germline variants in TPMT and NUDT15. However, a minority of patients who suffered such adverse drug reaction have NUD...

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Detalles Bibliográficos
Autores principales: Cao, Minyuan, Yin, Dandan, Qin, Yun, Liao, Fei, Su, Yali, Xia, Xuyang, Gao, Ju, Zhu, Yiping, Zhang, Wei, Shu, Yang, Lu, Xiaoxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098961/
https://www.ncbi.nlm.nih.gov/pubmed/32265697
http://dx.doi.org/10.3389/fphar.2020.00267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098961/
https://www.ncbi.nlm.nih.gov/pubmed/32265697
http://dx.doi.org/10.3389/fphar.2020.00267

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