Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity

CCL5 is a unique chemokine with distinct stage and cell-type specificities for regulating inflammation, but how these specificities are achieved and how CCL5 modulates immune responses is not well understood. Here we identify two stage-specific enhancers: the proximal enhancer mediates the constitut...

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Detalles Bibliográficos
Autores principales: Seo, Wooseok, Shimizu, Kanako, Kojo, Satoshi, Okeke, Arinze, Kohwi-Shigematsu, Terumi, Fujii, Shin-ichiro, Taniuchi, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099032/
https://www.ncbi.nlm.nih.gov/pubmed/32218434
http://dx.doi.org/10.1038/s41467-020-15375-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099032/
https://www.ncbi.nlm.nih.gov/pubmed/32218434
http://dx.doi.org/10.1038/s41467-020-15375-w

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