Cargando…
The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix, important to breast physiology and tumorigenesis, remains unclear. Here we report that bot...
Autores principales: | Ataca, Dalya, Aouad, Patrick, Constantin, Céline, Laszlo, Csaba, Beleut, Manfred, Shamseddin, Marie, Rajaram, Renuga Devi, Jeitziner, Rachel, Mead, Timothy J., Caikovski, Marian, Bucher, Philipp, Ambrosini, Giovanna, Apte, Suneel S., Brisken, Cathrin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099066/ https://www.ncbi.nlm.nih.gov/pubmed/32218432 http://dx.doi.org/10.1038/s41467-020-15357-y |
Ejemplares similares
-
Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development
por: Ataca, Dalya, et al.
Publicado: (2016) -
Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
por: Cagnet, Stéphanie, et al.
Publicado: (2018) -
Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation
por: Shamseddin, Marie, et al.
Publicado: (2021) -
Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate
por: Nandadasa, Sumeda, et al.
Publicado: (2023) -
ER and PR signaling nodes during mammary gland development
por: Tanos, Tamara, et al.
Publicado: (2012)