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Derivatives of activated H-ras lacking C-terminal lipid modifications retain transforming ability if targeted to the correct subcellular location
To examine the ability of ras to activate signal transduction pathways in the absence of lipid modifications, fusion proteins were constructed that target ras(WT) or activated ras(61L) to cellular membranes as integral membrane proteins, using the first transmembrane domain of the E1 protein of avia...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
1997
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100284/ https://www.ncbi.nlm.nih.gov/pubmed/9050994 http://dx.doi.org/10.1038/sj.onc.1200908 |