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Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy

Probenecid has been used for decades in the treatment of gout but recently has also been found to improve outcomes in patients with heart failure via stimulation of the transient receptor potential vanilloid 2 (TRPV2) channel in cardiomyocytes. This study tested the use of probenecid on a novel mous...

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Detalles Bibliográficos
Autores principales: Onusko, Evan, McDermott, Michael R., Robbins, Nathan, Liu, Guansheng, Kranias, Evangelia G., Rubinstein, Jack, Koch, Sheryl E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100971/
https://www.ncbi.nlm.nih.gov/pubmed/32218573
http://dx.doi.org/10.1371/journal.pone.0230386