A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

Asparaginyl endopeptidases (AEPs) catalyze the key backbone cyclization step during the biosynthesis of plant-derived cyclic peptides. Here, we report the identification of two AEPs from Momordica cochinchinensis and biochemically characterize MCoAEP2 that catalyzes the maturation of trypsin inhibit...

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Detalles Bibliográficos
Autores principales: Du, Junqiao, Yap, Kuok, Chan, Lai Yue, Rehm, Fabian B. H., Looi, Fong Yang, Poth, Aaron G., Gilding, Edward K., Kaas, Quentin, Durek, Thomas, Craik, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101308/
https://www.ncbi.nlm.nih.gov/pubmed/32221295
http://dx.doi.org/10.1038/s41467-020-15418-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101308/
https://www.ncbi.nlm.nih.gov/pubmed/32221295
http://dx.doi.org/10.1038/s41467-020-15418-2

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