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Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA

Replicative DNA polymerases (DNAPs) have evolved the ability to copy the genome with high processivity and fidelity. In Eukarya and Archaea, the processivity of replicative DNAPs is greatly enhanced by its binding to the proliferative cell nuclear antigen (PCNA) that encircles the DNA. We determined...

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Detalles Bibliográficos
Autores principales: Madru, Clément, Henneke, Ghislaine, Raia, Pierre, Hugonneau-Beaufet, Inès, Pehau-Arnaudet, Gérard, England, Patrick, Lindahl, Erik, Delarue, Marc, Carroni, Marta, Sauguet, Ludovic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101311/
https://www.ncbi.nlm.nih.gov/pubmed/32221299
http://dx.doi.org/10.1038/s41467-020-15392-9