Integrative differential expression and gene set enrichment analysis using summary statistics for scRNA-seq studies

Differential expression (DE) analysis and gene set enrichment (GSE) analysis are commonly applied in single cell RNA sequencing (scRNA-seq) studies. Here, we develop an integrative and scalable computational method, iDEA, to perform joint DE and GSE analysis through a hierarchical Bayesian framework...

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Detalles Bibliográficos
Autores principales: Ma, Ying, Sun, Shiquan, Shang, Xuequn, Keller, Evan T., Chen, Mengjie, Zhou, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101316/
https://www.ncbi.nlm.nih.gov/pubmed/32221292
http://dx.doi.org/10.1038/s41467-020-15298-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101316/
https://www.ncbi.nlm.nih.gov/pubmed/32221292
http://dx.doi.org/10.1038/s41467-020-15298-6

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