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Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain

Microglia, the brain-resident macrophages, exhibit highly dynamic functions in neurodevelopment and neurodegeneration. Human microglia possess unique features as compared to mouse microglia, but our understanding of human microglial functions is largely limited by an inability to obtain human microg...

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Detalles Bibliográficos
Autores principales: Xu, Ranjie, Li, Xiaoxi, Boreland, Andrew J., Posyton, Anthony, Kwan, Kelvin, Hart, Ronald P., Jiang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101330/
https://www.ncbi.nlm.nih.gov/pubmed/32221280
http://dx.doi.org/10.1038/s41467-020-15411-9

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