Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

Bacterial and archaeal CRISPR-Cas systems provide RNA-guided immunity against genetic invaders such as bacteriophages and plasmids. Upon target RNA recognition, type III CRISPR-Cas systems produce cyclic-oligoadenylate second messengers that activate downstream effectors, including Csm6 ribonuclease...

Descripción completa

Detalles Bibliográficos
Autores principales: Garcia-Doval, Carmela, Schwede, Frank, Berk, Christian, Rostøl, Jakob T., Niewoehner, Ole, Tejero, Oliver, Hall, Jonathan, Marraffini, Luciano A., Jinek, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101355/
https://www.ncbi.nlm.nih.gov/pubmed/32221291
http://dx.doi.org/10.1038/s41467-020-15334-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101355/
https://www.ncbi.nlm.nih.gov/pubmed/32221291
http://dx.doi.org/10.1038/s41467-020-15334-5

Ejemplares similares