Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes

Gpr27 is a highly conserved, orphan G protein coupled receptor (GPCR) previously implicated in pancreatic beta cell insulin transcription and glucose-stimulated insulin secretion in vitro. Here, we characterize a whole-body mouse knockout of Gpr27. Gpr27 knockout mice were born at expected Mendelian...

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Detalles Bibliográficos
Autores principales: Chopra, Deeksha G., Yiv, Nicholas, Hennings, Thomas G., Zhang, Yaohuan, Ku, Gregory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101378/
https://www.ncbi.nlm.nih.gov/pubmed/32221326
http://dx.doi.org/10.1038/s41598-020-62358-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101378/
https://www.ncbi.nlm.nih.gov/pubmed/32221326
http://dx.doi.org/10.1038/s41598-020-62358-4

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