Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via modulation of acid sphingomyelinase

Activation of acid sphingomyelinase (SMPD1) and the generation of ceramide is a critical regulator of apoptosis in response to cellular stress including radiation. Endothelial SMPD1 has been shown to regulate tumor responses to radiation therapy. We show here that the SMPD1 gene is regulated by a mi...

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Detalles Bibliográficos
Autores principales: Rana, Shushan, Espinosa-Diez, Cristina, Ruhl, Rebecca, Chatterjee, Namita, Hudson, Clayton, Fraile-Bethencourt, Eugenia, Agarwal, Anupriya, Khou, Sokchea, Thomas, Charles R., Anand, Sudarshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101391/
https://www.ncbi.nlm.nih.gov/pubmed/32221387
http://dx.doi.org/10.1038/s41598-020-62621-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101391/
https://www.ncbi.nlm.nih.gov/pubmed/32221387
http://dx.doi.org/10.1038/s41598-020-62621-8

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