Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts

Formaldehyde (FA) is a simple biological aldehyde that is produced inside cells by several processes such as demethylation of DNA and proteins, amino acid metabolism, lipid peroxidation and one carbon metabolism (1-C). Although accumulation of excess FA in cells is known to be cytotoxic, it is unkno...

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Detalles Bibliográficos
Autores principales: Nadalutti, Cristina A., Stefanick, Donna F., Zhao, Ming-Lang, Horton, Julie K., Prasad, Rajendra, Brooks, Ashley M., Griffith, Jack D., Wilson, Samuel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101401/
https://www.ncbi.nlm.nih.gov/pubmed/32221313
http://dx.doi.org/10.1038/s41598-020-61477-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101401/
https://www.ncbi.nlm.nih.gov/pubmed/32221313
http://dx.doi.org/10.1038/s41598-020-61477-2

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