New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis

Extracellular release of HMGB1 contributes to acetaminophen-induced liver injury. HMGB1 acts as a danger-associated molecular patterns during this toxic process but the mechanisms of action and targeted cells are incompletely defined. Here we studied, in vitro, the role of HMGB1 in amplifying the ac...

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Detalles Bibliográficos
Autores principales: Minsart, Charlotte, Liefferinckx, Claire, Lemmers, Arnaud, Dressen, Cindy, Quertinmont, Eric, Leclercq, Isabelle, Devière, Jacques, Moreau, Richard, Gustot, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101425/
https://www.ncbi.nlm.nih.gov/pubmed/32221312
http://dx.doi.org/10.1038/s41598-020-61270-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101425/
https://www.ncbi.nlm.nih.gov/pubmed/32221312
http://dx.doi.org/10.1038/s41598-020-61270-1

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