Proapelin is processed extracellularly in a cell line-dependent manner with clear modulation by proprotein convertases

Apelin is a peptide hormone that binds to a class A GPCR (the apelin receptor/APJ) to regulate various bodily systems. Upon signal peptide removal, the resulting 55-residue isoform, proapelin/apelin-55, can be further processed to 36-, 17-, or 13-residue isoforms with length-dependent pharmacologica...

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Detalles Bibliográficos
Autores principales: Shin, Kyungsoo, Landsman, Michael, Pelletier, Stephanie, Alamri, Bader N., Anini, Younes, Rainey, Jan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101949/
https://www.ncbi.nlm.nih.gov/pubmed/30430332
http://dx.doi.org/10.1007/s00726-018-2674-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101949/
https://www.ncbi.nlm.nih.gov/pubmed/30430332
http://dx.doi.org/10.1007/s00726-018-2674-8

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