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Proapelin is processed extracellularly in a cell line-dependent manner with clear modulation by proprotein convertases
Apelin is a peptide hormone that binds to a class A GPCR (the apelin receptor/APJ) to regulate various bodily systems. Upon signal peptide removal, the resulting 55-residue isoform, proapelin/apelin-55, can be further processed to 36-, 17-, or 13-residue isoforms with length-dependent pharmacologica...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Vienna
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101949/ https://www.ncbi.nlm.nih.gov/pubmed/30430332 http://dx.doi.org/10.1007/s00726-018-2674-8 |